Amira Khalafallah (2012-2014)
Structures and Enzymology of Fungal Biosynthetic Enzymes.
Fungi catalyse a highly diverse array of oxidative rearrangements which result in rapid creation of complex molecular motifs. We are studying different enzymes which catalyse the following reactions: TenA, a cytochrome P450 enzyme produced by Beauveria bassiana which encodes a 2-Pyridone synthase (part of the tenellin biosynthetic pathway). TropB, TropC, TropD and TropF from Talaromyces stipitatus are involved in the biosynthesis of the fungal tropolones which have many biological activities.