Biosynthesis of Xenovulenes in Filamentous Fungi
The compound Xenovulene A® (1) which inhibits the binding of benzodiazepines to the GABA‑benzodiazepine receptor is produced by the filamentous fungus Acremonium strictum. Previous feeding studies proposed a ring expansion-ring contraction mechanism to process the PKS derived product (2). The whole genome sequence will enable the identification of the gene cluster which contains the PKS and the tailoring enzymes. Knockout experiments will help to identify the role of each of the involved proteins and provide further knowledge of programming in PKS.
 M. Ainsworth, I. Chicarelli-Robinson, B. R. Copp, U. Fauth, P. J. Hylands, J. A. Holloway, M. Latif, G. B. O’Beirne, N. Porter, D. V. Renno, M. Richards, N. Robinson, J. Antibiot., 1995, 7, 568 – 573.
 M. E. Raggatt, T. J. Simpson, M. I. Chicarelli-Robinson, Chem. Commun., 1997, 22, 2245 – 2246.
 Picture: Raissa Schor.