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D. M. Roberts, C. Bartel, A. Scott, D. Ivison, T. J. Simpson, R. J. Cox  (2017): Substrate selectivity of an isolated enoyl reductase catalytic domain from an iterative highly reducing fungal polyketide synthase reveals key components of programming, Chemical Science 2017
DOI: 10.1039/C6SC03496A

E. Liddle, A. Scott, L-C. Han, D. Ivison, T. J. Simpson, C. L. Willis and R. J. Cox (2017): In Vitro Kinetic Study of the Squalestatin Tetraketide Synthase Dehydratase Reveals the Stereochemical Course of a Fungal Highly Reducing Polyketide Synthase, Chemical Communication 2017
DOI: 10.1039/C6CC10172K

F. Trenti, R. J. Cox (2017): Structural Revision and Biosynthesis of the Fungal Phytotoxins Phyllostictines A and B, J.Nat.Prod 2017
DOI: 10.1021/acs.jnatprod.7b00183

J. Feng, P. Zhang, K. Li, X. Qiao, Y. Zhang, S-M. Li, R. J. Cox, M. Ye, W-B. Yin (2017): Discovery of a Novel Phenolic Glycosyltransferase from Mucor hiemalis and Its Catalytic Promiscuity, Advanced Synthesis and Catalysis 2017
DOI: 10.1002/adsc.201601317

K. Williams, A. J. Szwalbe, C. Dickson, T. R. Desson, N. P. Mulholland, J. L. Vincent, J. M. Clough, A. M. Bailey, C. P. Butts, C. L. Willis, T. J. Simpson, R. J. Cox (2017): Genetic and Chemical Characterisation of the Cornexistin Pathway Provides Further Insight into Maleidride Biosynthesis, Chem. Commun, 2017, in press

S-S. Gao, L. Wang, Z. Song, J. Hothersall, E. R. Stevens, J. Connolly, P. J. Winn, R. J. Cox, M. P. Crump, P. R. Race, C. M. Thomas, T. J. Simpson, C. L. Willis (2017): Selected Mutations Reveal New Intermediates in the Biosynthesis of the Thiomarinol and Mupirocin Antibiotics, Angewandte Chemie 2017
DOI: 10.1002/anie.201611590

W. Chen, R. Chen, Q. Liu, Y. He, K. He, X. Ding, L. Kang, X. Guo, N. Xie, Y. Zhou, Y. Lu, R. J. Cox, I. Molnar, M. Li, Y. Shao, F. Chen (2017): Orange, red, yellow: biosynthesis of azaphilone pigments in Monascus fungi, Chemical Science 2017
DOI: 10.1039/c7sc00475c

A. Bailey, F. Alberti, S. Kilaru, C. Collins, K. de Mattos-Shipley, A. Hartley, P. Hayes, A. Griffin, C. Lazarus, R.J. Cox, C. WIllis, D. Spence, G. Foster (2016): Identification and mainpulation of the pleuromutilin gene cluster from Clitopilus passeckerianus for increased rapid antibiotic production, Nature Scientific Report 2016
DOI: 10.1038/srep25202

B. Bonsch, V. Belt, C. Bartel, N. Duensing, M. Konziol, C.M. Lazarus, A.M. Bailey. T.J. Simpson, R.J. Cox (2016): Identification of Genes Encoding Squalestatin S1 Biosynthesis and in vitro Production of New Squalestatin Analogues, Chemical communications 2016,
DOI: 10.1039/C6CC02130A

C.R. Jones, M.D. Greenhalgh, J.R. Bame, T.J. Simpson, R.J. Cox, J.W. Marshall, C.P. Butts (2016): Subtle Temperature-Induced Changes in Small Molecule Conformer Dynamics - Observed and Quantified by NOE Spectroscopy, Chem. Commun. 2016,
DOI: 10.1039/C5CC10509A

K. Williams, A.J. Szwalbe, N.P. Mulholland, J.L. Vincent, A.M. Bailey, C.L. Willis, T.J. Simpson, R.J Cox  (2016): Heterologous Production of Fungal Maleidrides Reveals the Cryptic Cyclisation Involved in their Biosynthesis, Angew.Chemie 2016
DOI: 10.1002/anie.201511882

S. Griffiths, C. H. Mesarich, B. Saccomanno, A. Vaisberg, P. J. G. M. de Wit, R. J. Cox, J. Collemare (2016): Elucidation of cladofulvin biosynthesis reveals a cytochrome P450 monooxygenase required for anthraquinone dimerization, PNAS USA 2016
DOI: 10.1073/pnas.1603528113

Y. He, R.J. Cox (2016): The Molecular Steps of Citrinin Biosynthesis in Fungi, Chemical Science 2016
DOI: 10.1039/C5SC04027B

A. Abooda, A. Al-Fahad, A. El-Dein, M. Hosny, A. M. Hashem, A. M. A. Fattah, P. R. Race, T. J. Simpson and R. J. Cox (2015): Kinetic characterisation of the FAD dependent monooxygenase TropB and investigation of its biotransformation potential, RSC Advances 2015,
DOI: 10.1039/C5RA06693J

A.J. Szwalbe, K.Williams, D.E. O'Flynn, A.M. Bailey, N.P. Mulholland, J.L. Vincent, C.L. Willis, R.J.Cox, T.J. Simpson (2015): Novel nonadride, heptadride and maleic acid metabolites from the byssochlamic acid producer Byssochlamys fulva IMI 40021 - an insight into the biosynthesis of maleidrides, Chem. Commun 2015
DOI: 10.1039/C5CC06988B

M. H. Medema, R. Kottmann, P. Yilmaz, R.J. Cox,  (2015): Minimum Information about a Biosynthetic Gene cluster, Nature Chemical Biology 2015
DOI: 10.1038/nchembio.1890

Y. He, R.J. Cox (2015): The Molecular Steps of Citrinin Biosynthesis in Fungi, Chemical Science 2015
DOI: 10.1039/C5SC04027B

Z. Song, W. Bakeer, J. W. Marshall, A. A. Yakasai, R. M. Khalid, J. Collemare, E. Skellam, D. Tharreau, M.-H. Lebrun, C. M. Lazarus, A. M. Bailey, T. J. Simpson and R. J. Cox (2015): Heterologous Expression of the Avirulence gene ACE1 from the fungal rice pathogen Magnoporthe oryzae, Chemical Science 2015
DOI: 10.1039/C4SC03707C

A. Al-Fahad, A. Abood, K. M. Fisch, A. Osipow, J. Davison, M. Avramovic, C. P. Butts, J. Piel, T. J. Simpson, R. J. Cox (2014): Oxidative Dearomatisation: The Key Step of Sorbicillinoid Biosynthesis, Chem. Sci. 2014, 5, 523-527.
DOI: 10.1039/C3SC52911H

A. Al-Fahad, A. Abood, T. J. Simpson, R. J. Cox (2014): The Biosynthesis and Catabolism of the Maleic Anhydride Moiety of Stipitatonic Acid, Angew. Chem. Int. Ed. 2014, 53 (29), 7519-7523
DOI: 10.1002/anie.201403450

A. C. Murphy, S. Gao, L. C. Han, S. Carobene, D. Fukuda, Z. Song, J. Hothersall, R. J. Cox, J. Crosby, M. P. Crump, C. M. Thomas, C. L. Willis, T. J. Simpson (2014): Biosynthesis of thiomarinol A and related metabolites of Pseudoalteromonas sp. SANK 73390, Chemical Science 2014, 5, 397-402.
DOI: 10.1039/c3sc52281d

A. Latif, S. H. Hussain, M. Ali, M. Arfan, M. Ahmed, R. J. Cox, T. J. Simpson, G. Uddin (2014): A New Antioxidant Triterpenoid from the Stem Wood of Sorbus lanata, Rec. Nat. Prod. 2014, 8, 19-24.

Bilal Ökmen, Jérôme Collemare, Scott Griffiths, Ate van der Burgt, Russell Cox and Pierre J. G. M. de Wit (2014): Functional analysis of the conserved transcriptional regulator CfWor1 in Cladosporium fulvum reveals diverse roles in the virulence of plant pathogenic fungi, MOLECULAR MICROBIOLOGY, 2014, 92, Issue 1, 10–27.
DOI: 10.1111/mmi.12535

Hussain, SH ; Latif, A ; Cox, RJ ; Simpson, TJ ; Ali, M ; Arfan, M ; Uddin, G (2014): Phytochemicals from the aerial parts of Ligularia thomsonii and their radical scavenging activity, PHYTOCHEMISTRY LETTERS, 2014, 7
DOI: 10.1016/j.phytol.2013.09.002

J. Collemare, S. Griffiths, Y. Iida, M. K. Jashni, E. Battaglia, R. J. Cox, P. J. G. M. de Wit (2014): Secondary Metabolism and Biotrophic Lifestyle in the Tomato Pathogen Cladosporium fulvum, PLoS ONE 2014, 9(1): e85877.
DOI: 10.1371/journal.pone.0085877

R. J. Cox (2014): β-Chain Extension: A New Mode of Carbon-Carbon Bond Formation and Chain Extension by Polyketide Synthases, ChemBioChem 2014, 15, 27-29.
DOI: 10.1002/cbic.201300660

R. J. Cox (2014): Oxidative Rearrangements during Fungal Biosynthesis, Nat. Prod. Rep. 2014, 31 (10), 1405-1424
DOI: 10.1039/C4NP00059E

S.-S. Gao, J. Hothersall, J. Wu, A. C. Murphy, Z. Song, E. R. Stephens, C. M. Thomas, M. P. Crump, Russell J Cox, T. J. Simpson, and C. L. Willis (2014): Biosynthesis of Mupirocin by Pseudomonas fluorescens NCIMB 10586 Involves Parallel Pathways, J. Am. Chem. Soc. 2014, 136, 5501–5507.
DOI: 10.1021/ja501731p

A. Munawar, J. W. Marshall, R. J. Cox, A. M. Bailey* and C. M. Lazarus* (2013): Isolation and Characterisation of a Ferrirhodin Synthetase Gene from the Sugarcane Pathogen Fusarium sacchari, ChemBioChem 2013, 14(3), 388-394.
DOI: 10.1002/cbic.201200587

A. S. Haines, X. Dong, Z. Song, R. Farmer, C. Williams, J. Hothersall, E. Płoskoń, P. Wattana-Amorn, E. R. Stephens, E. Yamada, R. Gurney, Y. Takebayashi, J. Masschelein, R. J. Cox, R. Lavigne, C. L. Willis, T. J. Simpson, J. Crosby, P. J. Winn, C. M. Thomas and M. P. Crump (2013): A conserved motif flags acyl carrier proteins for β-branching in polyketide synthesis, Nat. Chem. Biol. 2013, 9, 11, 685–692.
DOI: 10.1038/nchembio.1342

G. Uddin, A. Latif, M. Arfan, M. Ali, S. H. Hussain, T. J. Simpson, R. J. Cox and M. I. Choudhary (2013): Phytochemicals from the stem wood of Sorbus lanata (D. Don.) Schauer, Phytochem. Lett. 2013, 6(1), 84-89.
DOI: 10.1016/j.phytol.2012.10.002

M. V. Gammons, O. Fedorov, D. Ivison, C. Y. Du, T. Clark, C. Hopkins, M. Hagiwara, A. D. Dick, R. Cox, S. J. Harper, J. C. Hancox, S. Knapp and D. O. Bates (2013): Topical Antiangiogenic SRPK1 Inhibitors Reduce Choroidal Neovascularization in Rodent Models of Exudative AMD, Invest. Ophthalmol. Vis. Sci. 2013, 54, 9, 6052-6062.
DOI: 10.1167/iovs.13-12422

R. J. Cox, A. Al-Fahad (2013): Chemical mechanisms involved during the biosynthesis of tropolones, Curr. Opin. Chem. Biol., 2013, 17, 532-536. more

R. J. Cox, Z. Wasil, M. Pahirulzaman, C. Butts, T. J. Simpson and C. M. Lazarus (2013): One Pathway, Many Compounds: Heterologous Expression of a Fungal Biosynthetic Pathway Reveals its Intrinsic Potential for Diversity, Chem. Sci. 2013, 4, 3845.
DOI: 10.1039/C3SC51785C

S. H. Hussain, A. Latif, M. Arfan, M. Ali, T. J. Simpson, R. J. Cox, F. Shaheen, G. Uddin (2013): A New Bezoxepin Derivative from Senecio desfontainei, Rec. Nat. Prod. 2013, 7, 4, 325-331.

A K Pahirulzaman, K., Williams, K., and Lazarus, C.M. (2012): A Toolkit for Heterologous Expression of Metabolic Pathways in Aspergillus oryzae, Methods in Enzymology, 2012, 517, 241-260.

J. Davison, A. al Fahad, M. Cai, Z. Song, S. Yehia, C. M. Lazarus, A. M. Bailey, T. J. Simpson and R. J. Cox* (2012): Genetic, Molecular and Biochemical Basis of Fungal Tropolone Biosynthesis, Proc. Natl. Acad Sci USA 2012, 109(20), 7642-7647.

A. A. Yakasai, J. Davison, Z. Wasil, L. Halo, C. P. Butts, C. M. Lazarus, A. M. Bailey, T. J. Simpson and R. J. Cox* (2011): Nongenetic Reprogramming of a Fungal Highly Reducing Polyketide Synthase, J. Am. Chem. Soc., 2011, 133, 10990-10998.
DOI: 10.1021/ja204200x

A. C. Murphy, D. Fukuda, Z. Song, J. Hothersall, R. J. Cox, C. L. Willis, C. M. Thomas and T. J. Simpson* (2011): Engineered Thiomarinol Antibiotics Active against MRSA Are Generated by Mutagenesis and Mutasynthesis of Pseudoalteromonas SANK73390, Angew. Chem. Int. Ed., 2011, 50, 3271-3274.
DOI: 10.1002/anie.201007029

A. S. Evitt and R. J. Cox* (2011): Synthesis and Evaluation of Conformationally Restricted Inhibitors of Aspartate Semialdehyde Dehydrogenase, Mol. Biosyst., 2011, 7(5), 1564-1575.

D. Fukuda, A. S. Haines, Z. Song, A. Murphy, J. Hothersall, E. Stephens, R. Gurney, R. J. Cox, J. Crosby, C. Willis, T. J. Simpson, C. M. Thomas* (2011): A natural plasmid encoding two antibiotic synthases creates a potent conjugate active against MRSA, PLOS1, 2011, 6(3), e18031.

J. Hothersall, A. C. Murphy, Z. Iqbal, G. Campbell, E. R. Stephens, J. Wu, H. Cooper, S. Atkinson, P. Williams, J. Crosby, C. L. Willis, R. J. Cox, T. J. Simpson, C. M. Thomas (2011): Manipulation of quorum sensing regulation in Pseudomonas fluorescens NCIMB 10586 to increase mupirocin production, Appl. Microbiol. Biotechnol., 2011, 90(3), 1017-1026.

K. M. Fisch, W. Bakeer, A. A. Yakasai, Z. Song, J. Pedrick, Z. Wasil, A. M. Bailey, C. M. Lazarus, T. J. Simpson, and R. J. Cox* (2011): Rational Domain Swaps Decipher Programming in Fungal Highly Reducing Polyketide Synthases and Resurrect an Extinct Metabolite, J. Am. Chem. Soc., 2011, 133, 16635-16641.

M. N. Heneghan, A. A. Yakasai, K. Williams, K. A. Kadir, Z. Wasil, W. Bakeer, K. M. Fisch, A. M. Bailey, T. J. Simpson, R. J. Cox* and C. M. Lazarus (2011): The Programming Role of Trans-Acting Enoyl Reductases During the Biosynthesis of Highly Reduced Fungal Polyketides, Chem. Sci, 2011, 2(5), 972-979.

R. W. Scott, A. C. Murphy, J. Wu, J. Hothersall, R. J. Cox, T. J. Simpson, C. M. Thomas and C. L. Willis* (2011): Mupirocin F: structure elucidation, synthesis and rearrangements, Tetrahedron, 2011, 67, 5098-5106.

E. J. Skellam, D. Hurley, J. Davison, C. M. Lazarus, T. J. Simpson and R. J. Cox,* (2010): Mutation of Key Residues in the C-methyltransferase Domain of a Fungal Highly Reducing Polyketide Synthase, Mol. Biosyst., 2010, 6, 680-882.

J. Wu,* H. B. Zhang, J. L. Xu, R. J. Cox, T. J. Simpson and L. H. Zhang (2010): C-13 Labeling reveals multiple amination reactions in the biosynthesis of a novel polyketide polyamine antibiotic zeamine from Dickeya zeae, Chem. Commun., 2010, 46, 333-335.

K. M. Fisch, E. Skellam, D. Ivison, R. J. Cox,* A. M. Bailey, C. M. Lazarus and T. J. Simpson (2010): Catalytic Role of the C-Terminal Domains of a Fungal Non-Reducing Polyketide Synthase, Chem. Commun., 2010, 46, 5331-5333.

M. N. Heneghan, A. A. Yakasai, L. M. Halo, Z. Song, A. M. Bailey, R. J. Cox*, T. J. Simpson and C. M. Lazarus (2010): The First Heterologous Reconstruction of a Complete Functional Fungal Biosynthetic Multi-Gene Cluster, ChemBioChem, 2010, 11, 1508-1512.

P. Wattana-Amorn, C. Williams, E. Ploskon, R. J. Cox, T. J. Simpson, J. Crosby, M. P. Crump (2010): Solution Structure of an Acyl Carrier Protein Domain from a Fungal Type I Polyketide Synthase, Biochemistry, 2010, 49, 2186-2193.

Russell J. Cox* and Thomas J. Simpson,* (2010): Fungal Type I Polyketides, in Comprehensive Natural Products II: Volume 1, p 347-383, Elsevier, 2010.

P. Beltran-Alvarez, C. J. Arthur, R. J. Cox,* J. Crosby, M. P. Crump and T. J. Simpson (2009): Preliminary Kinetic Analysis of Acyl Carrier Protein:Ketoacylsynthase Interactions in the Actinorhodin Minimal Polyketide Synthase, Molcular Biosystems, 2009, 5, 511-518.

R. J. Cox,* T. J. Simpson,* (2009): Fungal Type I Polyketide Synthases, Complex Enzymes In Microbial Natural Product Biosynthesis, Part B: Polyketides, Aminocoumarins And Carbohydrates, Methods In Enzymology, 2009, 459, 49-78.

S. E. Evans, C. Williams, C. J. Arthur, E. Ploskon, P. Wattana-Amorn, R. J. Cox, J. Crosby, C. L. Willis, T. J. Simpson and M. P. Crump,* (2009): Probing the Interactions of Early Polyketide Intermediates with the Actinorhodin ACP from S. coelicolor A3(2), J. Mol. Biol., 2009, 389, 511-528.

J. Wu, J. Hothersall, C. Mazzetti, Y. O’Connell, J. A. Shields, A. S. Rahman, R. J. Cox, J. Crosby, T. J. Simpson,* C. M. Thomas and C. L. Willis (2008): In vivo Mutational Analysis of the Mupirocin Gene Cluster Reveals Labile Points in the Biosynthetic Pathway: the 'Leaky Hosepipe' Mechanism, ChemBioChem, 2008, 9, 1500-1508.

L. M. Halo, J. W. Marshall, A. A. Yakasai, Z. Song, C. P. Butts, M. P. Crump, M. Heneghan, A. M. Bailey, T. J. Simpson, C. M. Lazarus, and R. J. Cox,* (2008): Authentic Heterologous Expression Of The Tenellin Iterative Polyketide Synthase Non-Ribosomal Peptide Synthetase requires co-expression with an enoyl reductase, ChemBioChem, 2008, 9, 585-594.

L. M. Halo, M. N. Heneghan, A. A. Yakasai, Z. Song, K. Williams, A. M. Bailey, R. J. Cox,* C. M. Lazarus, and T. J. Simpson (2008): Late stage oxidations during the biosynthesis of the 2-pyridone tenellin in the entomopathogenic fungus Beauveria bassiana, J. Am. Chem. Soc., 2008, 130, 17988-17996.

R. J. Cox and T. J. Simpson,* (2008): Polyketide Biosynthesis, Fungi, Wiley Encyclopaedia of Chemical Biology, August 15th, 2008.
DOI: 10.1002/9780470048672.wecb458

A. M. Bailey, R. J. Cox,* K. Harley, C. M. Lazarus, T. J. Simpson* and E. Skellam (2007): Characterisation of 3-methylorcinaldehyde synthase (MOS) in Acremonium strictum: first observation of a reductive release mechanism during polyketide biosynthesis, Chem. Commun., 2007, 4053-4055.

D. O. Rees, N. Bushby, R. J. Cox, J. R. Harding, T. J. Simpson* and C. L. Willis,* (2007): Synthesis of 1,2-13C215N.-L-Homoserine and Incorporation by the PKS-NRPS System of Fusarium moniliforme into the Mycotoxin Fusarin C, ChemBioChem, 2007, 8, 46-50.

I. Eleftherianos, S. Boundy, S. A. Joyce, J. W. Marshall, R. J. Cox, T. J. Simpson, D. J. Clarke, R. H. ffrench-Constant and S. E. Reynolds,* (2007): An antibiotic produced by an insect-pathogenic bacterium inhibits host defences through phenoloxidase inhibition, Proc. Natl. Acad. Sci. USA, 2007, 104(7), 2419-2424.

J. Hothersall, J. Wu, A. S. Rahman, J. A. Shields, J. Haddock, N. Johnson, S. M Cooper, E. Stephens, R. J. Cox, J. Crosby, C. L. Willis, T. J Simpson and C. M. Thomas* (2007): Mutational analysis reveals that all tailoring region genes are required for production of polyketide antibiotic mupirocin by Pseudomonas fluorescens: Pseudomonic acid B biosynthesis precedes pseudomonic acid, J. Biol. Chem., 2007, 282, 15451-15461.

J. Wu, S. M. Cooper, R. J. Cox, J. Crosby, M. P. Crump, J. Hothersall, T. J. Simpson,* C. M. Thomas and C. L. Willis (2007): Mupirocin H, a novel metabolite resulting from mutation of the HMG-CoA synthase analogue, mupH in Pseudomonas fluorescens, Chem. Commun., 2007, 2040-2042.

K. L. Eley, L. M. Halo, Z. Song, H. Powles, R. J. Cox,* A. M. Bailey, C. M. Lazarus and T. J. Simpson (2007): Biosynthesis of the 2-Pyridone Tenellin in the Insect Pathogenic Fungus Beauveria bassiana, ChemBioChem, 2007, 8, 289-297.
DOI: 10.1002/cbic.200600398

P. Beltran-Alvarez, R. J. Cox,* J. Crosby and T. J. Simpson (2007): Dissecting the Component Reactions Catalysed by the Actinorhodin Minimal Polyketide Synthase, Biochemistry, 2007, 46, 14672-14681.

R. J. Cox* (2007): Polyketides, Proteins and Genes in Fungi: Programmed Nano-Machines Begin to Reveal Their Secrets, Org. Biomol. Chem., 2007, 5, 2010-2026.

R. J. Cox* (2007): The Biosynthesis of polyketides, tetramic acids and pyridones in fungi, ACS Symposium Series on Polyketides: Biosynthesis, Biological Activity and Genetic Engineering, 2007, 955, chapter 3, 33-47.

R. J. Cox* and A. S. Evitt (2007): Acyl Palladium Species in Synthesis: Single Step Synthesis of α,β-Unsaturated Ketones from Acid Chlorides, Org. Biomol. Chem., 2007, 5, 229-232.

R. J. Cox* and U. Wong (2007): The Chemical Mechanism of D-1-deoxyxylulose-5-phosphate reductoisomerase from Escherichia coli, Angew. Chem. Int Ed. Engl., 2007, 46, 4926-4929.

C. J. Arthur, A. E. Szafranska, J. Long, J. Mills, R. J. Cox, S. C. Findlow, T. J. Simpson, M. P. Crump and J. Crosby* (2006): The malonyl transferase activity of type II polyketide synthase acyl carrier proteins, Chem. Biol., 2006, 13, 587-596.

Y. Ma, L. H. Smith, R. J. Cox,* P. Beltran-Alvarez, C. J. Arthur and T. J. Simpson (2006): Catalytic Relationships between Type I and Type II Iterative Polyketide Synthases: The Aspergillus parasiticus Norsolorinic Acid Synthase, ChemBioChem, 2006, 7, 1951-1958.

L. Mercklé, A. de Andrés-Gómez, B. Dick, R. J. Cox* and C. R. A. Godfrey (2005): A Fragment-Based Approach to Understanding Inhibition of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase, ChemBioChem, 2005, 6, 1866-1874.

R. J. Cox,* D. J. Ritson, T. A. Dane, J. Berge, J. P. H. Charmant and A. Kantacha (2005): Room Temperature Palladium Catalysed Coupling of Acyl Chlorides with Terminal Alkynes, Chem. Commun., 2005, 1037-1039.

R. J. Cox,* J. S. Gibson and A. T. Hadfield (2005): Design, Synthesis and Analysis of Inhibitors of Bacterial Aspartate Semi-aldehyde Dehydrogenase, ChemBioChem, 2005, 6, 2255-2260
DOI: 10.1002/cbic.200500172

S. M. Cooper, R. J. Cox, J. Crosby, M. P. Crump, J. Hothersall, W. Laosripaiboon, T. J. Simpson* and C. M. Thomas (2005): Mupirocin W, a Novel Pseudomonic Acid Produced by Targeted Mutation of the Mupirocin Biosynthetic Gene Cluster, Chem. Commun., 2005, 1179-1181.

S.M. Cooper, W. Laosripaiboon, J. Hothersall, A. K. El-Sayed, C. Winfield, J. Crosby, R. J. Cox, T. J. Simpson and C. M. Thomas,* (2005): Shift to Pseudomonic Acid B Production in Pseudomonas fluorescens NCIMB 10856 by Mutation of Mupirocin Tailoring Genes mupO, mupU and mupV, Chem. Biol., 2005, 12, 825-833.

L. A. Adams, J. P. H. Charmant, R. J. Cox,* M. Walter and W. G. Whittingham (2004): Efficient Synthesis of Protected Cyclopropyl β-Aspartylphosphates, Org. Biomol. Chem., 2004, 2, 542-553.

R. J. Cox* and F. Glod (2004): Fungal Secondary Metabolism in the Information Age, in Advances in Fungal Biotechnology for Industry, Agriculture, and Medicine, Kluwer Press, 2004, New York, pp 69-81.

R. J. Cox,* F. Glod, D. Hurley, C. M. Lazarus, T. P. Nicholson, B. A. M. Rudd, T. J. Simpson, B. Wilkinson and Y. Zhang (2004): Rapid Cloning and Expression of a Fungal Polyketide Synthase Gene Involved in Squalestatin Biosynthesis, Chem. Commun., 2004, 20, 2260-2261.

R. J. Cox,* F. Glod, T. J. Simpson, C. M. Lazarus and Z. Song (2004): Biosynthesis of Fusarin C in Fusarium moniliforme and Fusarium venenatum, ChemBioChem, 2004, 5, 1196-1203.
DOI: 10.1002/cbic.200400138

R. J. Cox,* J. Berge and D. J. Ritson (2004): Indium Mediated Allylation of Glyoxylate Oxime Ethers, Esters and Cyanoformates, Org. Biomol. Chem., 2004, 2, 1921-1933.

W. Teartasin, C. Limpkin, F. Glod, J. Spencer, R. J. Cox, T. J. Simpson, J. Crosby, M. P. Crump, and A. T. Hadfield,* (2004): Expression, Purification and Preliminary X-ray Diffraction Analysis of a Ketoreductase from a Type II Polyketide Synthase, Acta Cryst. Sect. D., 2004, 60, 1137-1138.

L. A. Adams, V. K. Aggarwal,* R. V. Bonnert, B. Bressel, R. J. Cox,* J. Shepherd, J. de Vicente, M. Walter and W. Whittingham (2003): Diastereoselective Synthesis of Cyclopropane Amino Acids Using Diazo Compounds Generated In Situ, J. Org. Chem., 2003, 68, 9433-9440.

M. A. C. Reed, M. Schweizer, A. E. Szafranska, C. Arthur, T. P. Nicholson, R. J. Cox, J. Crosby,* M. P. Crump and T. J. Simpson (2003): The isolated Acyl Carrier Protein Domain from the Type I Rat Fatty Acid Synthase Shows Considerable Homology and Analogous Biochemical Properties to Type II Acyl Carrier Proteins, Organic and Biomolecular Chemistry, 2003, 1, 463-471.

R. J. Cox,* A. de Andres-Gomez and C. R. A. Godfrey (2003): Rapid and flexible synthesis of 1-deoxy-D-xylulose-5-phosphate, the substrate for 1-deoxy-D-xylulose-5-phosphate reductoisomerase, Org. Biomol. Chem., 2003, 1, 3173-3177.

T. P. Nicholson, C. Winfield, J. Westcott, J. Crosby, T. J. Simpson, and R. J. Cox,* (2003): First in vitro directed biosynthesis of new compounds by a minimal Type II polyketide synthase: evidence for the mechanism of chain length determination, J. Chem. Soc., Chem. Commun., 2003, 686-687.

C. Arthur, R. J. Cox,* J. Crosby, M. M. Rahman, T. J. Simpson, F. Soulas, R. Spogli, A. E. Szafranska, J. Westcott and C. J. Winfield (2002): Synthesis and Characterisation of Acyl Carrier Protein Bound Polyketide Analogues, ChemBioChem, 2002, 3, 253-257.

L. A. Adams, R. J. Cox,* J. S. Gibson, M. B. Mayo-Martín, M. Walter and W. Whittingham (2002): A New Synthesis of Phosphoramidates: Inhibitors of Aspartate Semi-Aldehyde Dehydrogenase, J. Chem. Soc., Chem. Commun., 2002, 2004-2005.

R. J. Cox* (2002): Reductive Hydrazination of α-ketoacid; Hydrazine carboxylic acid, Synthetic Page 192, 2002, more
DOI: 10.1039/SP192

R. J. Cox* (2002): Epoxidation of an α-keto ester; Epoxide, Synthetic Page 194, 2002, more
DOI: 10.1039/SP194

R. J. Cox* (2002): Formation of N-Acyl Phosphoramidates; Phosphoramidate, Synthetic Page 201, 2002, more
DOI: 10.1039/SP201

R. J. Cox,* (2002): Biosynthesis, Annu. Rep. Prog. Chem., Sect. B: Org. Chem., 2002, 98, 223-251.

R. J. Cox,* J. Crosby, O. Daltrop, F. Glod, M. Jarzabek, T. P. Nicholson, T. J. Simpson, F. Soulas and J. Westcott (2002): Cloning, expression and substrate activity of , J. Chem. Soc., Perkin Trans 1, 2002, 1644-1649.

R. J. Cox,* J. Durston, and D. I. Roper (2002): Synthesis and in vitro Enzyme Activity of an Oxa Analogue of Azi-DAP, J. Chem. Soc. Perkin Trans 1., 2002, 1029-1035.

R. J. Cox,* J. S. Gibson and B. Mayo-Martin (2002): Synthesis and in vitro activity of the first synthetic inhibitors of Aspartate semi-aldehyde dehydrogenase, ChemBioChem, 2002, 3, 864-876.

T. S. Hitchman, A. E. Szafranska, R. J. Cox,* J. Crosby* and T. J. Simpson,* (2002): Kinetic and Mechanistic Analysis of the Malonyl-CoA:ACP Transacylase from Streptomyces coelicolor Indicates a Single Catalytically Competent Serine Nucleophile at the Active Site, Biochemistry, 2002, 41(5), 1421-1427.

R. J. Cox* and P. S. H. Wang (2001): Synthesis and in vitro enzyme activity of aza, oxa and thia derivatives of bacterial cell wall biosynthesis intermediates, J. Chem. Soc., Perkin Trans. 1, 2001, 2022-2034.

R. J. Cox* and P. S. H. Wang (2001): Is N-acetylornithine aminotransferase the real N-succinyl-LL-diaminopimelate aminotransferase in Escherichia coli and Mycobacterium smegmatis?, J. Chem. Soc., Perkin Trans. 1, 2001, 2006-2008.

R. J. Cox,* A. Hadfield and M. B. Mayo-Martin (2001): Difluoromethylene analogues of aspartyl phosphate: the first synthetic inhibitors of aspartate semi-aldehyde dehydrogenase, J. Chem. Soc., Chem. Commun., 2001, 1710-1711.

T. P. Nicholson, B. A. M. Rudd, M. Dawson, C. M. Lazarus, T. J. Simpson and R. J. Cox,* (2001): Design and utility of oligonucleotide gene probes for fungal polyketide synthases, Chem. Biol., 2001, 8, 157-178.

R. J. Cox,* (2000): Biosynthesis, Annu. Rep. Prog. Chem., Sect. B: Org. Chem., 2000, 96, 231-258.

R. J. Cox,* A. Sutherland, J. C. Vederas,* (2000): Bacterial Diaminopimelate Metabolism as a Target for Antibiotic Design, Bioorg. Med. Chem., 2000, 8, 843-871.

R. J. Cox,* H. Jenkins, J. A. Schouten, R. A. Stentiford and K. J. Wareing (2000): Synthesis and in vitro enzyme activity of peptide derivatives of bacterial cell wall biosynthesis inhibitors, J. Chem. Soc. Perkin Trans. 1, 2000, 2023-2036.

C. Bisang, P. F. Long J. Cortes, J. Westcott, J. Crosby, A-L Matharu, R. J. Cox, T. J. Simpson, J. Staunton and P. F. Leadlay,* (1999): A chain initiation factor common to both modular and aromatic polyketide synthases, Nature, 1999, 401, 502-505.

A-L. Matharu, R. J. Cox, J. Crosby, K. J. Byrom and T. J. Simpson,* (1998): MCAT is not required for in vitro polyketide synthesis in a minimal actinorhodin polyketide synthase from Streptomyces coelicolor, Chem. Biol., 1998, 5, 699-711.

J. Crosby, K. J. Byrom, T. S. Hitchman, R. J. Cox, M. P. Crump, I. S. C. Findlow, M. Bibb and T. J. Simpson,* (1998): Acylation of Streptomyces Type II polyketide synthase acyl carrier proteins, FEBS Lett., 1998, 433, 132-138.

M. C. Moore, R. J. Cox, G. R. Duffin, and D. O'Hagan,* (1998): Synthesis and evaluation of a putative acyl tetramic acid intermediate in tenellin biosynthesis in Beauveria bassiana. A new role for tyrosine, Tetrahedron, 1998, 54, 9195-9206.

R. J. Cox,* (1998): Biosynthesis, Annu. Rep. Prog. Chem., Sect. B: Org. Chem., 1998, 94, 187-206.

R. J. Cox,* J. A. Schouten, R. A. Stentiford and K. J. Wareing (1998): Peptide inhibitors of N-Succinyl Diaminopimelic Acid Aminotransferase (DAP-AT): A novel class of antimicrobial compounds, Bioorg. Med. Chem. Lett., 1998, 8, 945-950.

T. S. Hitchman, J. Crosby, K. J. Byrom, R. J. Cox and T. J. Simpson,* (1998): Catalytic self-acylation of Type II polyketide synthase acyl carrier proteins, Chem. Biol., 1998, 5, 35-47.

R. J. Cox,* T. S. Hitchman, K. J. Byrom, I. S. C. Findlow, J. A. Tanner, J. Crosby and T. J. Simpson (1997): Post-translational modification of heterologously expressed Streptomyces Type II polyketide synthase acyl carrier proteins, FEBS Lett., 1997, 405, 267-272.

R. J. Cox, W. A. Sherwin, L. K. P. Lam and J. C. Vederas,* (1996): Synthesis and evaluation of novel substrates and inhibitors of N-Succinyl-LL-diaminopimelate aminotransferase (DAP-AT) from Escherichia coli, J. Am. Chem. Soc., 1996, 118, 7449-7460.

R. J. Cox,* (1996): The DAP Pathway to Lysine as a Target for Antimicrobial Agents, Nat. Prod. Rep., 1996, 13, 29-43.

R. J. Cox and D. O'Hagan,* (1991): Synthesis of isotopically labelled 3-amino-2-phenylpropionic acid and its role as a precursor in the biosynthesis of tenellin and tropic acid, J. Chem. Soc., Perkin Trans. 1, 1991, 2537-2540.